Gliadin (Deamidated Peptide) Antibody (IgG)

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Anti-Gliadin Antibody (IgG), Celiac Disease, Gliadin Deamidated Peptide Antibody IgG, Gluten IgG (Gliadin)

Gliadin (Deamidated)

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The Gliadin (Deamidated Peptide) Antibody (IgG) test contains 1 test with 1 biomarker.

Detection of antibodies to gliadin, one of the major protein components of gluten, is a sensitive assay useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.

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